|
名稱 |
Rat / Mouse TGF-beta 1 / TGFB1 Protein/重組大鼠/小 |
|
規(guī)格 |
20ug |
|
編號 |
CZDB-014 |
|
價格 |
詢價 |
|
中文名 |
Rat / Mouse TGF-beta 1 / TGFB1 Protein/重組大鼠/小 |
|
分子別稱 |
TGFB1 |
|
分子種屬 |
Mouse |
|
表達(dá)標(biāo)簽 |
His，S |
|
表達(dá)宿主 |
E. coli |
|
濃度 |
> 95 % as determined by SDS-PAGE |
|
緩沖液 |
Lyophilized from sterile PBS, pH 7.4 |
|
存儲條件 |
-70°C，應(yīng)避免反復(fù)凍融。 |
|
基本描述 |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression. |
